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CycleFem Duo

Take care of your menstrual health with CycleFem Duo

An innovative dual-release product for the management of premenstrual syndrome symptoms and dysmenorrhea.

Menstrual disorders: Symptoms, Diagnosis, and Possible Causes

Premenstrual syndrome (PMS) is a condition that affects individuals who menstruate, typically occurring in the luteal phase of the menstrual cycle, which is the time between ovulation and the start of menstruation.

It is characterized by a combination of physical, emotional, and behavioral symptoms that can significantly impact daily life. Diagnosis is primarily clinical, based on symptom tracking for at least two consecutive menstrual cycles.

Globally, PMS affects a substantial portion of menstruating individuals, with prevalence estimates ranging from 30% to 80%, depending on diagnostic criteria and population studies.

Severe forms of PMS, known as premenstrual dysphoric disorder (PMDD), impact around 3% to 8% of individuals, leading to more intense psychological distress.

Additionally, many individuals with PMS also experience dysmenorrhea, or painful menstrual cramps, which can further contribute to discomfort and reduce quality of life.


The exact cause of PMS remains unclear, but it is believed to result from hormonal fluctuations, particularly in estrogen and progesterone levels, as well as neurotransmitter changes involving serotonin.

Genetic predisposition, lifestyle factors such as diet and stress, and underlying health conditions may also contribute to symptom severity.

Common symptoms include mood swings, irritability, anxiety, depression, bloating, breast tenderness, fatigue, headaches, and food cravings.

Dysmenorrhea, which often coexists with PMS, is characterized by cramping pain in the lower abdomen, sometimes accompanied by nausea, dizziness, and lower back pain.

While symptoms vary in intensity, they typically subside once menstruation begins.

Managing PMS and dysmenorrhea effectively involves lifestyle modifications, dietary support, and targeted nutraceutical interventions that help balance hormonal fluctuations, reduce inflammation, and alleviate discomfort, promoting overall well-being.

CycleFem Duo: Innovative Solution for Menstrual Health

CycleFem Duo offers a unique and effective solution for PMS and dysmenorrhea with innovative technology and clinically tested ingredients.

  • Innovative double-release technology (intestine-intestine). Guaranteed protection and bioavailability of the synbiotic (prebiotic and probiotic), thanks to the CIC system.
  • Unique mechanism of action. Regulates gut-brain axis.
  • The first product on the market to target two menstrual disorders (PMS and dysmenorrhea).
  • A complete formula offering a synergistic effect, unique in the market for reducing PMS symptoms and dysmenorrhea.
  • Scientifically supported. High-quality clinically tested ingredients.

Innovative Double-Release Technology

CycleFem Duo’s unique dual-capsule system ensures the probiotic is delivered correctly to the intestine, where it exerts its specific effect.

  • EXTERNAL CAPSULE
    An external capsule that delivers the ingredient at the intestinal stage: Probiotic protected from interactions with components of the inner capsule to guarantee stability of the synbiotic. By targeting the gut-brain axis, the synbiotic corrects the imbalance in the gut microbiota (dysbiosis).

    COMPOSITION

    Synbiotic:

    • Bifidobacterium breve
    • FOS

  • INTERNAL CAPSULE
    An internal capsule that delivers the ingredient in the intestinal phase: Intestinal absorption of the components. Ginger extract and Vitex are primarily absorbed in the small intestine.

    COMPOSITION

    Ginger, vitex, vitamin B6, magnesium and vitamin D

  • CycleFem Duo is an alternative and efficient solution to current treatment options for PMS. Moreover, thanks to its innovative CIC system, the probiotic is protected from potential interactions with the rest of the formula.

Clinical Evidence

Objective: A randomized control trial was conducted on our B. breve strain to evaluate its efficacy in managing major depression disorder.

Results:

  • The B. breve significantly reduced emotional disorders (anxiety and depression) compared to the placebo.
  • Gastrointestinal dysfunction is one of the most comorbid symptoms of depression, and the B. breve showed a better effect especially in attenuating bowel dysfunction syndrome compared to the placebo.

Objective: A real-world, open-label study was conducted with 64 participants experiencing varying severities of PMS symptoms. Participants were categorized into three groups: Group A (received standard therapies), Group B (received Vitex, vitamin B6, and magnesium), and Group C (received both A and B therapies).

 

Results:

  • The results of this study conclude that the nutraceutical group (group B) significantly improved anxiety and mood swings in subjects with PMS.
  • Moreover, a combination of Vitex, vitamin B6, and magnesium reduced menstrual backache, cramps, depression, headaches, and fatigue in PMS patients.

Everything You Need to Know

CycleFem Duo is an alternative and efficient solution to current treatment options for PMS and dysmenorrhea.

CycleFem Duo is recommended for women experiencing menstrual disorders, including:

  • Treatment of PMS symptoms and dysmenorrhea.
  • Coadjuvant therapy to standard treatments, such as nonsteroidal anti-inflammatory drugs (NSAIDs), painkillers, or antidepressants.

CycleFem Duo offers multiple benefits through:

  • Mood modulation (Gut-brain axis).
  • Anti-inflammatory effect.
  • Hormonal balance.
  • Antioxidant effect.
  • Treatment: Take 1 cap/day as an initial treatment; increase to 2 caps/day if needed.
  • Coadjuvant Therapy: If used alongside anti-inflammatory drugs, painkillers, or antidepressants, take 1 cap/day.
  • Treatment Duration: Use for at least three consecutive cycles.
  • Prebiotics: Ingredients that are selectively utilized by host microorganisms and confer a beneficial health effect. They serve as food for the beneficial microorganisms that live on or in us.
  • Probiotics: Live microorganisms that, when administered in adequate amounts, produce a health benefit to the host.

A synbiotic is the combination of a probiotic and a prebiotic to enhance the beneficial effects of both.

 Because of the possible dopaminergic and oestrogenic effects of Vitex agnus castus, fructus interactions with dopamine agonists, dopamine antagonists, oestrogens and antioestrogens cannot be excluded.

About Aora Health

Nutraceutical Research and Development Company

We are part of AORA Health, a nutraceutical research and development company.

We create innovative, scientifically proven solutions with specific benefits designed to complement or replace pharmaceuticals.

Our mission is to improve people’s well-being through nutraceutical products with proven benefits and the backing of science.